Sign Up



Order controlled substances safely, securely, and efficiently



Aleady Have a Digital Certificate?

 Go here to order now.


How do I sign up?


  1. interactive connection   Enroll
  2.    Install
  3. Word to html   Call
  4. replace text   Test


1. Enroll

Before you can use PuraGraft’s CSOS to order Schedule II items, you must first obtain a CSOS Certificate from the DEA.

A CSOS Certificate is a digital identity issued by the DEA and is the digital equivalent of the identification information contained on a DEA Form 222.
Log onto the DEA’s e-commerce website and follow the on-screen instructions:
If you have additional questions or concerns, the DEA offers the following support, Mondays through Fridays from 8:00 AM through 8:00 PM (Eastern Time):
Phone: 1-877-DEA-ECOM (1-877-332-3266) toll-free

2. Install

To retrieve and install your new certificate, use the Access Code you recieved in your email. Note: This must be done within 60 days of the date printed on your mailed notice.


2. Call

Call us at 877-540-3258 to be added to our e222 ordering page and receive login instructions.


2. Test

Perform the digital certificate test and email test on the ordering site. If the test was successful proceed to the customer area, otherwise, give us a call at 877-540-3258.





How Long Will it Take to Receive my CSOS Certificate?


You should receive your CSOS Certificate activation notice within thirty days of submitting your complete DEA application package.  Incomplete, inaccurate, or invalid application packages will take longer to process and may be denied and returned by the DEA.


Application packages can take up to two weeks to be received by the DEA's CSOS Registration Authority, and then typically take seven to 10 business days to process.  If the application is approved, you will receive an activation notice via one or more of the following methods:


Postal mail:  Allow seven to 10 business days for the Activation Notice to arrive; and/or

E-mail:  The DEA sends Activation Notices via email to applicants upon approval.


Controlled Substance Ordering System (CSOS)

Under the authority of the Controlled Substances Act of 1970, the Drug Enforcement Administration (DEA), Office of Diversion Control (OD) regulates the manufacture and distribution of controlled substances in the United States. 


This regulatory control is designed to prevent the diversion of legitimate pharmaceutical drugs into illegal channels and to ensure that there is a sufficient supply for legitimate medical uses.  


The DEA’s CSOS program allows for secure electronic controlled substances orders without having to complete the supporting paper DEA Form 222.  Using a technology called PKI, CSOS requires each individual purchaser to enroll with the DEA to acquire a CSOS digital certificate.


Using CSOS provides many benefits to our customers, including:


  • Ordering Freedom: CSOS transactions are the only allowance for electronic ordering of Schedule I and II controlled substances, but may also be used for Schedule III-V substances. Additionally, CSOS has no line item limit for a single order.


  • Faster Transactions: CSOS Certificates contain the same identification information as DEA Form 222, allowing for timely and accurate validation by the supplier.  Faster transactions allow for just-in-time ordering and smaller inventories.


  • Accurate Orders: CSOS reduces the number of ordering errors.


  • Decreased Cost: Order accuracy and decreased paperwork result in a lower transaction cost.